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KMID : 1007520160250041169
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Food Science and Biotechnology
2016 Volume.25 No. 4 p.1169 ~ p.1174
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Antioxidant and anti-adipogenic activities of chestnut (Castanea crenata) byproducts
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Youn Un-Young
Shon Myung-Soo
Kim Gyo-Nam
Katagiri Riho
Harata Kaori
Ishida Yasuyuki
Lee Seung-Cheol
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Abstract
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The antioxidant and anti-adipogenic activities of chestnut byproducts were evaluated. At 100 μg/mL, the methanol extract (ME) scavenged 34.2% of DPPH and 78.8% of ABTS radicals. The DPPH and ABTS radical scavenging activity of the water extract (WE) was found to be low (13.7 and 33.1%, respectively) compared with controls. WE and ME dose-dependently inhibited lipid accumulation of 3T3-L1 adipocytes. WE and ME at 100 μg/mL suppressed 3T3-L1 adipogenesis by 71.0 and 96.5%, respectively, when compared with mature adipocytes. The results indicated that WE and ME inhibited adipocyte differentiation by down-regulating the mRNA expression levels of CCAAT/enhancer binding protein (C/EBP)-β, C/EBPα, and peroxisome proliferator-activated receptor (PPAR)-γ in 3T3-L1 cells. Our study also revealed that WE and ME inhibited pre- and early stage adipogenesis in 3T3-L1 cells. The results suggest that chestnut byproducts are a promising source of antioxidant and antiobesity molecules.
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KEYWORD
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chestnut, byproducts, antioxidant activity, gallic acid
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